A new simple, rapid, accurate, sensitive and precise spectrophotometric method in colorimetric region has been developed for determination of Ezetimibe in bulk and pharmaceutical dosage form by MBTH reagent. The principle involved in this method is iron catalysed coupling reaction of MBTH with the drug in the presence of Fecl3 to form green colored coumpound which exhibited maximum absorbance at 621 nm in methnol. Beer''s law was found to be obeyed in the concentration range 20-100 �µg/mL. Regression equation was found to be 0.009x and coefficient of correlation was 0.9922. The developed method was validated respect to stability, linearity, precision, accuracy. The proposed method is useful for the routine estimation of Ezetimibe in bulk and pharmaceutical dosage form.
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